Recombinant human CTLA-4 protein

Proteins

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. It also is a protein receptor that functions as an immune checkpoint and downregulates immune responses. This protein is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation a phenomenon which is particularly notable in cancers. It may also function via modulation of cell motility and signaling through PI3 kinase. It has been implicated in several autoimmune diseases, such as systemic lupus erythematosus. Recombinant human CTLA-4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Immunology

< 1 EU per 1ug of protein (determined by LAL method)

ATGP3334 has been replaced with a catalog number ATGP3918.

Human

Cytotoxic T lymphocyte protein 4 isoform CTLA4-TM precursor, Cytotoxic T-lymphocyte-associated antigen 4, CTLA 4, CTLA4, CTLA-4, CD 152, CD152, CELIAC3, CELIAC 3, Celiac disease 3, Insulin-dependent diabetes mellitus 12, Insulin dependent diabetes mellitus 12, IDDM 12, IDDM12, CD, GSE, ATGP3918-10ug, ATGP3918-20ug, ATGP3918-50ug, ATGP3918-100ug, ATGP3918-250ug, ATGP3918-500ug, ATGP3918-1mg, ATGP3918-010, ATGP3918-020, ATGP3918-050, ATGP3918-100, ATGP3918-250, ATGP3918-500, ATGP3918-01M, ATGP3334