Comparison

Recombinant human IL-33 protein

Item no. NKM-ILC0701-100ug
Manufacturer NKMAX
Amount 100 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
Citations Schmitz., et al. (2005) immunity 23(5):479-90
Baekkevold, E.S., et al. (2003) Am. J.Pathol. 163(1):69-90

Ito R, et al. A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis. (JCI Insight. 2018){https://pubmed.ncbi.nlm.nih.gov/30385714/}
NCBI NP_254274
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Interleukin-33,Interleukin-1 family member 11,IL-1F11,Nuclear factor from high endothelial venules,NF-HEV,DVS27-related protein,DVS27,C9orf26
Similar products IL-33, IL33, C9orf26, IL1F11, NFHEV, Nuclear factor from high endothelial venules, DKFZp586H0523, DVS27, NF-HEV, IL 33, DVS27 related protein, IL 1F11, Interleukin 1 family member 11, Interleukin 33, Interleukin 33 precursor, Interleukin33, NF HEV, RP11 575C20.2, NKHEV, Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26, INTERLEuKIN 33 NFHEV, il33, ILC0701-10ug, ILC0701-20ug, ILC0701-50ug, ILC0701-100ug, ILC0701-250ug, ILC0701-500ug, ILC0701-1mg, ILC0701-10, ILC0701-20, ILC0701-50, ILC0701-100, ILC0701-250, ILC0701-500, ILC0701-1
Available
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
18.1 kDa (160aa) confirmed by MALDI-TOF
Description
Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1. Recombinant human IL-33(C-terminal fragment) was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0)
Antigen Species
Human
Gene Category
Hormones & Cytokines
Domain
112-270aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 range ≤ 0.3ng/ml.
Species of Protein
Human
Manufacturer - Search Terms
IL33, Interleukin 33, DVS27, NF-HEV, NKHEV, C9orf26, IL-33, Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26, DKFZp586H0523, DVS27 related protein, IL 1F11, IL 33, IL1F11, Interleukin 1 family member 11, INTERLEuKIN 33 NFHEV, Interleukin 33 precursor, Interleukin33, NF HEV, NFHEV, Nuclear factor from high endothelial venules, RP11 575C20.2, il33, ILC0701-10ug, ILC0701-20ug, ILC0701-50ug, ILC0701-100ug, ILC0701-250ug, ILC0701-500ug, ILC0701-1mg, ILC0701-10, ILC0701-20, ILC0701-50, ILC0701-100, ILC0701-250, ILC0701-500, ILC0701-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
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