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MMP1 Recombinant Protein (Human)

MMP1 Recombinant Protein (Human)

Item no.	OPED00090
Manufacturer	AVIVA Systems Biology
Amount	10 ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins Cell Biology Cell Stainings ECM
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>95% (SDS-PAGE)
Dry ice	Yes
Citations	Enzymatic, physicochemical and biological properties of MMP-sensitive alginate hydrogels: K.B. Fonseca, et al.; Soft Matter 9, 3283 (2013), Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeutics: T.J. Edkins, et al.; J. Pharm. Biomed. Anal. 70, 408 (2012), Abstract; Directed evolution of protease beacons that enable sensitive detection of endogenous MT1-MMP activity in tumor cell lines: A. Jabaiah, et al.; Chem. Biol. 18, 392 (2011), Abstract; Full Text Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors: M. Gooyit, et al.; Chem. Biol. Drug Des. 74, 535 (2009), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CLG;CLGN;fibroblast collagenase;interstitial collagenase;matrix metallopeptidase 1 (interstitial collagenase);matrix metalloprotease 1;Matrix metalloproteinase-1.
Shipping Condition	Dry ice
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	20 kDa
Manufacturer - Application Additional Information	Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors.
Gene symbol	MMP1
Gene Fullname	matrix metallopeptidase 1
Protein size	Recombinant
Product format	Liquid. In 50mM TRIS, pH 7.5, containing 5mM calcium chloride, 300mM sodium chloride, 20 uM zinc chloride, 0.5% Brij-35, and 30% glycerol.
Reconstitution and storage	Store at -80C
Description of target	Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).
Nucleotide accession_num	NM_001190942.1
Protein accession_num	NP_001177871.1
Protein name	Interstitial collagenase
Purification	Purified by multi-step chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 12/25/2025

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