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Recombinant Human UBE2L3 Protein

Recombinant Human UBE2L3 Protein

Item no.	RP00025LQ-100ug
Manufacturer	Abclonal
Amount	100 ug
Quantity options	100 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Purity	> 95% by SDS-PAGE.
Dry ice	Yes
Sequence	MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
NCBI	UBE2L3
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	UBE2L3,E2-F1,L-UBC,UBCH7,UbcM4,Ube2L3 / UBCH7
Shipping Condition	Dry ice
Available
Manufacturer - Applications	Please contact us for more information.
Manufacturer - Category	Proteins
Shipping Temperature	dry ice
Storage Conditions	Store at -70°C. This product is stable at ≤ -70°C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.
Protein Weight	18.70 kDa
Description	Recombinant Human UBE2L3 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Asp154) of human UBE2L3 (Accession #NP_003338.1) fused with a 6×His tag at the C-terminus.
Background	Ubiquitin-conjugating Enzyme E2L 3 (UBE2L3), also known as Ubiquitin-conjugating Enzyme H7 (UbcH7), is a member of the Ubiquitin-conjugating (E2) enzyme family (1). The human UbcH7 protein shares 100% amino acid (aa) sequence identity with the mouse and rat orthologs. UBE2L3 is catalytically active with HECT and RBR domain-containing families of Ubiquitin ligases (E3s). UBE2L3 localizes to both the nucleus and cytoplasm in human cells. UBE2L3 depletion results in an extended S phase and a reduced rate of proliferation, suggesting that it may play a role in the cell cycle. In humans, single nucleotide polymorphisms in UBE2L3 are associated with systemic lupus erythematosus and Crohn's disease, suggesting that UbcH7 is important for proper immune system function.
Immunogen	Met1-Asp154
Route	C-His
Manufacturer - Research Area	Other Recombinant Protein
Antigen Seq	MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
Protein Formulation	Supplied in 50mM HEPES，200mM NaCl，10%glycerol，1mM TCEP，pH 7.0Contact us for customized product form or formulation.
Expected Protein Size	18.70 kDa
Gene Symbol	UBE2L3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/31/2025

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