Recombinant Human MANF Protein

< 1.0 EU/μg of the protein by LAL method.

ice pack

19.00 kDa

The protein is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing this protein increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

C-His

ARMET, ARP

Lyophilized from a 0.22 μm filtered solution of 20mM PIPES, 500mM NaCl, pH 6.0.Contact us for customized product form or formulation.

MANF