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Recombinant Human LEPTIN

Recombinant Human LEPTIN

Item no.	229-20189
Manufacturer	Raybiotech
Amount	1 mg
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins Obesity Endocrine Regulation of Lipid Metabolism
Type	Proteins
Format	Lyophilized
Applications	WB, ELISA, FA
Specific against	Human (Homo sapiens)
Host	Hamster - Armenian
Purity	>98% by SDS PAGE and HPLC analysis.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Category	Proteins and Peptides\|Recombinant Proteins
Shipping Temperature	Ambient temperature
Storage Conditions	-20°C
Molecular Weight	16.0kD (147 amino acid residues).
Description	Purified recombinant leptin expressed in E.coli. Sterile filtered through a 0.2 micron filter.
Format	Purified recombinant protein - lyophilized
Formulation	Lyophilized with 0.1% TFA
Protein Name & Synonyms	LEPTIN
UNSPSC Code	12352202
Concentration	ca.1.0 mg/ml after reconstitution
Reconstitution	Reconstitute with 1.0 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. RayBiotech recommends that the vial is gently mixed after reconstitution. For extended storage, the addition of 0.1% bovine serum abumin (BSA) is recommended.
Endotoxin Level	<1EU/ug
Preservative	None present
Introduction	Leptin is a major adipose-derived hormone and member of the leptin family, which plays a key role in appetite control and the regulation of energy expenditure. Secreted leptin associates with proteins within the bloodstream and is transported to the brain, where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognised marker of obesity, with a correlation between circulating levels of leptin and body fat mass, and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin, cortisol, cAMP and thiazolidinediones.
Biological activity	129-20189 is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µ g Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

229-20189.pdf

229-20189-datasheet.pdf

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Amount: 1 mg

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Delivery expected until 7/31/2025

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