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Recombinant Human PAI-1

Recombinant Human PAI-1

Item no.	229-20190
Manufacturer	Raybiotech
Amount	10 ug
Category	Oncology Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Senescence By Organ Breast Cancer Pancreatic Cancer Functional Assays
Type	Proteins
Format	Lyophilized
Applications	FA
Specific against	Human (Homo sapiens)
Host	Hamster - Armenian
Purity	>95% by SDS PAGE and HPLC analysis.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping Condition	Room temperature
Available
Manufacturer - Category	Proteins\|Recombinant Proteins\|Human Proteins
Shipping Temperature	Ambient temperature
Storage Conditions	-20°C
Molecular Weight	42.7kD (379 amino acid residues).
Description	Purified recombinant PAI-1 expressed in E.coli.
UNSPSC Code	12352202
Formulation	10mM Sodium Phosphate
Protein Name & Synonyms	PAI-1,
Format	Purified recombinant protein - lyophilized
Concentration	~0.1mg/ml after reconstitution
Reconstitution	Reconstitute with 100ul distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. RayBiotech recommends that the vial is gently mixed after reconstitution. For extended sotrage, the addition of 0.1% BSA is recommended.
Endotoxin Level	<1EU/ug
Preservative	None present
Biological activity	Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37°, C. Half maximal inhibition against 1.0 ug/ml of single chain tPA was obtained at a concentration of 2.0 ug/ml.
Introduction	PAI-1 (plasminogen activator inhibitor-1) is a serine protease inhibitor and member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis. Increased levels of PAI-1 are associated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity, and can be induced by obesity related factors including insulin, glucose and VLDL (very-low-density lipoprotein).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

229-20190.pdf

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Amount: 10 ug

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Delivery expected until 11/13/2025

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