AZ11645373

Non Antibodies

P2X7 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

463, 51

A Potent and Selective Antagonist of Human P2X7 Receptors

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

41116134

AZ11645373 is a potent and selective antagonist of human P2X7 purinergic receptors (KB = 5-20 nM), significantly less active on rat receptors, and inactive on other P2X receptor subtypes1.

Yes

AZ11645373 is a potent and highly selective antagonist of the human P2X7 receptor. It demonstrates IC50 values ranging from 5 to 90 nm depending on the cellular assay1. AZ11645373 is inactive on other P2X receptor subtypes and significantly less active on rat receptors1.The P2X7 receptor is a member of ligand-gated ion channels activated by extracellular ATP. This family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are highly expressed throughout autonomic, sensory and central neurons and in visceral smooth muscle, immune cells and epithelia1, 2.