UNI418

Item no.	HY-163943-10mg
Manufacturer	MedChem Express
CASRN	1802068-51-4
Amount	10 mg
Quantity options	1 ea 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Citations	[1]Seo, et al. "A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells." Experimental & Molecular Medicine (2024): 1-14.
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	PIKfyve; SARS-CoV
Shipping Temperature	Room temperature
Product Description	UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC50=1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC50=60.1 nM; Kd=61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (Kd=0.78 nM) to prevent SARS-CoV-2 from entering host cells[1].
Manufacturer - Research Area	Infection
Manufacturer - Pathway	Anti-infection; PI3K/Akt/mTOR
Clinical information	No Development Reported

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