UNI418

Item no.	HY-163943-10mM
Manufacturer	MedChem Express
CASRN	1802068-51-4
Amount	10mM/1mL
Quantity options	1 ea 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Purity	99.61
Smiles	C1(C2=CC=NC=C2)=NC(NC3=NNC(C4=CC=CC=C4)=C3)=C5C=CC=CC5=N1
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	PIKfyve; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	364.40
Product Description	UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 ( EC 50 =1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C ( IC 50 =60.1 nM; K d =61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve ( K d =0.78 nM) to prevent SARS-CoV-2 from entering host cells [1] .
Manufacturer - Research Area	Infection
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Anti-infection; PI3K/Akt/mTOR
Clinical information	No Development Reported

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