« Back
Home /
Z-IETD-FMK

Z-IETD-FMK

Item no.	V0030-50mg
Manufacturer	InvivoChem LLC
CASRN	210344-98-2
Amount	50 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 2 mg 5 mg
Category	Neuroscience Neuroinflammation Cell Biology Cell Status Apoptosis Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0030CAS #:210344-98-2Purity >=98% Description: Z-IETD-FMK (also known as Z-IE(OMe)TD(OMe)-FMK) is a novel, specific, selective, irreversible and cell permeable Caspase-8/9 inhibitor. Z-IETD-FMK acts by inhibiting T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. Z-IETD-FMK has no effect on normal cell growth when there is no activation signal. Z-IETD-FMK has also been found to significantly inhibit NF-kappaB activation when the concentration is 100uM. Apart from the ability of inhibiting cell proliferation, Z-IETD-FMK is reported to inhibit TRAIL-mediated killing in cells. It protects the procaspases 9, 2, and 3, and protects PARP to a similar extent in both HCT116 and SW480 cells. References: Toxicol Appl Pharmacol. 2012 Nov 15; 265(1):103-12; Cancer Res. 2000 Nov 15; 60(22):6259-65.
Molecular Weight (MW)	654.68
Formula	C30H43FN4O11
CAS No.	210344-98-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 91 mg/mL (138.99 mM)
	Water:< 1 mg/mL (slightly soluble or insoluble)
	Ethanol: < 1 mg/mL
Other info	Synonym: Z-IE(OMe)TD(OMe)-FMK; Granzyme B Inhibitor III; Z-IETD-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH?F. Chemical Name: (5S, 8S, 11S, 14S)-5-((S)-sec-butyl)-8-(2-carboxyethyl)-14-(2-fluoroacetyl)-11-((R)-1-hydroxyethyl)-3, 6, 9, 12-tetraoxo-1-phenyl-2-oxa-4, 7, 10, 13-tetraazahexadecan-16-oic acid InChi Key: CTXDBLYOEUERAT-VUVYEONESA-N InChi Code: InChI=1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9, 15-16, 18-19, 23-24, 34H, 4, 10-14H2, 1-3H3, (H, 30, 41)(H, 31, 42)(H, 32, 40)(H, 33, 43)(H, 36, 37)(H, 38, 39)/t15-, 16+, 18-, 19-, 23-, 24-/m0/s1 SMILES Code: O=C(O)C[CH](C(CF)=O)NC([CH]([CH](O)C)NC([CH](CCC(O)=O)NC([CH]([CH](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Chemical Name	L-Threoninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 23 days

Compare

Add to wishlist

Get an offer