SGC707

Item no.	V0383-1g
Manufacturer	InvivoChem LLC
CASRN	1687736-54-4
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0383CAS #:1687736-54-4Purity >=98% Description: SGC707 (SGC-707) is a novel, cell-permeable and allosteric PRMT3 inhibitor (protein arginine methyltransferase 3 inhibitor) with potential anticancer activity. It inhibits PRMT3 with an IC50 and a Kd of 31 nM and 53 nM, respectively. PRMT3 is involved in cancer development via interaction with the DAL-1 tumor suppressor protein. SGC707 is a chemical probe acting by inhibiting the activity of PRMT3 via targeting the dimerization interface of PRMT3. Description: References: Angew Chem Int Ed Engl. 2015 Apr 20; 54(17):5166-70; Epigenomics. 2015; 7(8):1327-38. References:
Molecular Weight (MW)	298.34
Formula	C16H18N4O2
CAS No.	1687736-54-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 59 mg/mL (197.7 mM)
	Water: < 1 mg/mL
	Ethanol: 59 mg/mL (197.7 mM)
Other info	Chemical Name: N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea InChi Key: DMIDPTCQPIJYFE-UHFFFAOYSA-N InChi Code: InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6, 9-10H, 1-2, 7-8, 11H2, (H2, 18, 19, 22) SMILES Code: O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2
Synonyms	SGC707; SGC 707; SGC-707

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