SGC77

InvivoChem Cat #: V0383
CAS #: 1687736-54-4
Purity >=98%



Description:
SGC707 (SGC-707) is a novel, cell-permeable and allosteric PRMT3 inhibitor (protein arginine methyltransferase 3 inhibitor) with potential anticancer activity. It inhibits PRMT3 with an IC50 and a Kd of 31 nM and 53 nM, respectively. PRMT3 is involved in cancer development via interaction with the DAL-1 tumor suppressor protein. SGC707 is a chemical probe acting by inhibiting the activity of PRMT3 via targeting the dimerization interface of PRMT3.

Description:

References:
Angew Chem Int Ed Engl. 2015 Apr 20; 54(17):5166-70; Epigenomics. 2015; 7(8):1327-38.

References:

C16H18N4O2

-20C for 3 years in powder form
-80C for 2 years in solvent

Chemical Name: N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea
InChi Key: DMIDPTCQPIJYFE-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6, 9-10H, 1-2, 7-8, 11H2, (H2, 18, 19, 22)
SMILES Code: O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2