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GNE-9605

GNE-9605

Item no.	V0774-100mg
Manufacturer	InvivoChem LLC
CASRN	1536200-31-3
Amount	100 mg
Quantity options	10 mg 1 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Cell Biology Cell Stainings ECM Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0774CAS #:1536200-31-3Purity >=98% Description: GNE-9605 (GNE 9605; GNE9605) is a novel, brain-penetrant, highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with anti-PD (Parkinson's disease) activity. It inhibits LRRK2 with a Ki and an IC50 of 2 nM and 19 nM, respectively. In human hepatocytes and liver microsomes, GNE-9605 exhibited excellent human metabolic stability. References: J Med Chem. 2014 Feb 13; 57(3):921-36.
Molecular Weight (MW)	449.83
Formula	C17H20ClF4N7O
CAS No.	1536200-31-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 89 mg/mL (197.8 mM)
	Water: < 1 mg/mL
	Ethanol: 12 mg/mL (26.7 mM)
Other Info	Chemical Name: N2-(5-chloro-1-((3R, 4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2, 4-diamine. InChi Key: PUXPEQJKNAWNQA-DGCLKSJQSA-N InChi Code: InChI=1S/C17H20ClF4N7O/c1-23-15-10(17(20, 21)22)4-24-16(27-15)26-12-5-25-29(14(12)18)13-2-3-28(6-11(13)19)9-7-30-8-9/h4-5, 9, 11, 13H, 2-3, 6-8H2, 1H3, (H2, 23, 24, 26, 27)/t11-, 13-/m1/s1 SMILES Code: FC(C1=CN=C(NC2=C(Cl)N([CH]3[CH](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
Synonyms	GNE-9605; GNE 9605; GNE9605;

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 10/2/2025

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