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GNE-9605

GNE-9605

Item no.	V0774-500mg
Manufacturer	InvivoChem LLC
CASRN	1536200-31-3
Amount	500 mg
Quantity options	100 mg 10 mg 1 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0774CAS #:1536200-31-3Purity >=98% Description: GNE-9605 (GNE 9605; GNE9605) is a novel, brain-penetrant, highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with anti-PD (Parkinson's disease) activity. It inhibits LRRK2 with a Ki and an IC50 of 2 nM and 19 nM, respectively. In human hepatocytes and liver microsomes, GNE-9605 exhibited excellent human metabolic stability. References: J Med Chem. 2014 Feb 13; 57(3):921-36.
Molecular Weight (MW)	449.83
Formula	C17H20ClF4N7O
CAS No.	1536200-31-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 89 mg/mL (197.8 mM)
	Water: < 1 mg/mL
	Ethanol: 12 mg/mL (26.7 mM)
Other Info	Chemical Name: N2-(5-chloro-1-((3R, 4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2, 4-diamine. InChi Key: PUXPEQJKNAWNQA-DGCLKSJQSA-N InChi Code: InChI=1S/C17H20ClF4N7O/c1-23-15-10(17(20, 21)22)4-24-16(27-15)26-12-5-25-29(14(12)18)13-2-3-28(6-11(13)19)9-7-30-8-9/h4-5, 9, 11, 13H, 2-3, 6-8H2, 1H3, (H2, 23, 24, 26, 27)/t11-, 13-/m1/s1 SMILES Code: FC(C1=CN=C(NC2=C(Cl)N([CH]3[CH](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
Synonyms	GNE-9605; GNE 9605; GNE9605;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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Delivery expected until 10/2/2025

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