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Pimozide

Pimozide

Item no.	HY-12987-100mg
Manufacturer	MedChem Express
CASRN	2062-78-4
Amount	100 mg
Quantity options	100 mg 10mM/1mL 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.91
Formula	C28H29F2N3O
Citations	[1]Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256(2):141-7. [2]Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017. [3]Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117(12): 3421-3429.
Smiles	O=C1NC2=CC=CC=C2N1C3CCN(CCCC(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	R6238
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Adrenergic Receptor; Dopamine Receptor; Parasite; STAT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	461.55
Product Description	Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
Manufacturer - Research Area	Cancer; Neurological Disease; Endocrinology
Solubility	DMSO : 16.67 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; JAK/STAT Signaling; Neuronal Signaling; Stem Cell/Wnt
Isoform	STAT3; STAT5
Clinical information	Launched

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HY-12987-100mg-safety-datasheet.pdf