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SB1-G-187

SB1-G-187

Item no.	HY-137342-100mg
Manufacturer	MedChem Express
CASRN	2769753-18-4
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.70
Formula	C52H54F3N9O10
Citations	[1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.
Smiles	O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3OCC(NCCOCCOCCOCCCN4CCN(CC5=C(C(F)(F)F)C=C(NC(C6=CC(C#CC7=CN=C8N7N=CC=C8)=C(C)C=C6)=O)C=C5)CC4)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	PROTACs
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	1022.03
Product Description	SB1-G-187, a PROTAC, is a multi-kinase degrader[1]. SB1-G-187 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	PROTAC
Clinical information	No Development Reported

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HY-137342-100mg-safety-datasheet.pdf