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IL-6R / CD126 Neutralizing Antibody

IL-6R / CD126 Neutralizing Antibody

Item no.	10398-MM08-500
Manufacturer	Sino Biological
Amount	500 ug
Quantity options	200 ug 500 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Carcinoma Hematology Leukemia Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Primary Antibodies
Type	Antibody Monoclonal
Clone	3H7D3H1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	sino
Available
Manufacturer - Type	Antibody
Storage Conditions	This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Antigen molecule name	IL6R
Immunogen	Recombinant Human IL-6R / CD126 protein (Catalog#10398-H08H)
Purification	Protein A
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; Catalog#10398-H08H; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Specificity	Human IL-6R / CD126
Buffer	0.2 um filtered solution in PBS (pH7.4) + 5% Trehalose Dihydrate
No cross-reactivity	No cross-reactivity with rat IL6R (81072-R02H), mouse IL6R (50280-M08H) and canine IL6R (70117-D08H) in ELISA assay
Block	This IL6R Neutralizing Antibody can not block the binding of recombinant IL6 (10395-HNAE) to its recombinant receptor IL6 Ralpha (10398-H08H).
Neutralization	The neutralization activity of IL6R Neutralizing Antibody is measured by its ability to neutralize IL6 Ralpha-mediated inhibition of proliferation in the M1 mouse myeloid leukemia cell line. The Neutralization Titer (IC50) is typically 0.15-0.6 ug/mL in the presence of 50 ng/mL Recombinant Human IL6 Ralpha (10398-H08H) and 100 ng/mL Recombinant Human IL6 (10395-HNAE).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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