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TNF-alpha / TNFA Neutralizing Antibody

TNF-alpha / TNFA Neutralizing Antibody

Item no.	10602-MM0N1-200
Manufacturer	Sino Biological
Amount	200 ug
Quantity options	200 ug 500 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Primary Antibodies
Type	Antibody Monoclonal
Clone	MM0N1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	sino
Available
Manufacturer - Type	Antibody
Storage Conditions	This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Antigen molecule name	TNF
Immunogen	Recombinant Human TNF-alpha / TNFA Protein (Catalog#10602-HNAE)
Purification	Protein A
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNF-alpha / TNFA (rh TNF-alpha / TNFA; Catalog#10602-HNAE; NP_000585.2; Val77-Leu233). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Specificity	Human TNF-alpha / TNFA
Buffer	0.2 um filtered solution in PBS
Block	This TNFa neutralizing antibody can block the binding of recombinant TNFa (10602-HNAE) to its recombinant receptors TNFR1 (10872-H08H) and TNFR2 (10417-H08H).
Neutralization	The neutralization activity of antibody is measured by its ability to neutralize TNFa induced cytotoxicity in the L-929 mouse fibroblast cell line. The Neutralization titer (IC50) is typically 13.5-54 ng/mL in the presence of 2 ng/mL Recombinant Human TNFa and 1 ug/mL actinomycin D.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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