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Recombinant Human ACVR2B Protein (ECD, hFc Tag), HPLC-verified

Recombinant Human ACVR2B Protein (ECD, hFc Tag), HPLC-verified

Item no.	10229-H02H-100
Manufacturer	Sino Biological
Amount	100 ug
Quantity options	1 mg 100 ug 2 mg 4 mg
Category	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Human Cell
Specific against	Human (Homo sapiens)
Host	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Activin RIIB, ActR-IIB, ACTRIIB, HTX4
Similar products	ACVR2B
Available
Manufacturer - Category	Protein
Molecule	ACVR2B
Synonym	Activin RIIB, ActR-IIB, ACTRIIB, HTX4
Storage	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Protein Construction	A DNA sequence encoding the N-terminal segment (Met 1-Thr 134) from the extracellular domain of human ACVR2B (NP_001097.2) was expressed with the fused human IgG1 Fc region at the C-terminus.
Expressed Host	Human Cells
Purity	> 97 % as determined by SDS-PAGE
Bio-Activity	1. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.02-0.1 ug/mL in the presence of 10 ng/mL recombinant Activin A. 2. Measured by its binding ability in a functional ELISA. 3. Immobilized human ACVR2B (Cat:10229-H02H) at 10 ug/mL (100 ul/well) can bind biotinylated human INHBA-His (Cat:10429-H08H), The EC50 of biotinylated human INHBA-His (Cat:10429-H08H) is 0.112 ug/mL. 4. Immobilized human ACVR2B (Cat:10229-H02H) at 10 ug/mL (100 ul/well) can bind biotinylated mouse INHBA-His (Cat:Cat:50659-M08H), The EC50 of biotinylated mouse INHBA-His (Cat:Cat:50659-M08H) is 0.161 ug/mL.
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Ser 19
Molecule Mass	The recombinant human ACVR2B/Fc chimera is a disulfide-linked homodimer generated after removal of the signal peptide. The reduced monomer comprises 354 amino acids and predicts a molecular mass of 40.0 kDa. As a result of glycosylation, the monomer migrates as an approximately 60-65 kDa protein in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4
Accession	NP_001097.2
Amino acid sequence	Met1-Thr134
TAG	C-human IgG1-Fc

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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10229-H02H-100-datasheet.pdf

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Amount: 100 ug

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