Anti-mGluR2/3 antibody (KLH)

Polyclonal

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.

P31421

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR2 subunit has been shown to be required for long-term potentiation at the mossy fiber input in the hippocampus (Yokoi et al., 1996).

Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

Is widely distributed in the CNS and prominent expression is seen in Golgi cells of the cerebellum and some particular neuronal cells in other brain regions.

110/220 kDa

Anti-Metabotropic Glutamate Receptor 2 antibody
Anti-Mglur2 antibody
Anti-Grm2 Gprc1b Mglur2 antibody

FOR RESEARCH USE ONLY (RUO).