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Anti-MYOC antibody

Anti-MYOC antibody

Manufacturer	St John's Laboratory
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Isotype	IgG
Applications	WB
Amount	50ul
Host	Rabbit
Item no.	STJ24669-50
eClass 6.1	32160702
eClass 9.0	32160702
Available
Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	Q99972
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
Gene ID	4653
Gene symbol	MYOC
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 245-504 of human MYOC (NP_000252. 1).
Short Description	Rabbit polyclonal against MYOC
Tissue specificity	Detected in aqueous humor. Detected in the eye (at protein level). Widely expressed. Highly expressed in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and bone marrow-derived mesenchymal stem cells. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and seems to be expressed at higher levels than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and to a lesser extent in iris and ciliary body.
Cellular localization	Secreted Golgi Apparatus Cytoplasmic Vesicle Extracellular Space Extracellular Matrix Extracellular Exosome Mitochondrion Mitochondrion Intermembrane Space Mitochondrion Inner Membrane Mitochondrion Outer Membrane Rough Endoplasmic Reticulum Cell Projection Cilium Located Preferentially In The Ciliary Rootlet And Basal Body Of The Connecting Cilium Of Photoreceptor Cells And In The Rough Endoplasmic Reticulum It Is Only Imported To Mitochondria In The Trabecular Meshwork Localizes To The Golgi Apparatus In Schlemm's Canal Endothelial Cells Appears In The Extracellular Space Of Trabecular Meshwork Cells By An Unconventional Mechanism Likely Associated With Exosome-Like Vesicles Localizes In Trabecular Meshwork Extracellular Matrix Myocilin C-Terminal Fragment: Secreted N-Terminal Fragment: Endoplasmic Reticulum Remains Retained In The Endoplasmic Reticulum
Molecular weight	Calculated: 56kDa. Observed: 65kDa
Dilution range	WB 1:500-1:2000
Alternative names	Anti-Myocilin antibody Anti-Myocilin 55 Kda Subunit antibody Anti-Trabecular Meshwork-Induced Glucocorticoid Response Protein Cleaved Into-Myocilin-N-Terminal Fragment antibody Anti-Myocilin 20 Kda N-Terminal Fragment-Myocilin-C-Terminal Fragment antibody Anti-Myocilin 35 Kda N-Terminal Fragment antibody Anti-MYOC GLC1A TIGR antibody
Protein name	Myocilin Myocilin 55 Kda Subunit Trabecular Meshwork-Induced Glucocorticoid Response Protein Cleaved Into-Myocilin-N-Terminal Fragment Myocilin 20 Kda N-Terminal Fragment-Myocilin-C-Terminal Fragment Myocilin 35 Kda N-Terminal Fragment
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	MYOC_HUMAN

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50ul

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Delivery expected until 6/6/2024