Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Isotype |
IgG |
Applications |
WB |
Amount |
50ul |
Host |
Rabbit |
Item no. |
STJ27622-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P00750 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-320 of human PLAT (NP_000921. 1). |
Short Description |
Rabbit polyclonal against PLAT |
Tissue specificity |
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk. |
Cellular localization |
SecretedExtracellular Space |
Molecular weight |
Calculated: 32kDa/44kDa/57kDa/62kDa. Observed: 63kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Tissue-Type Plasminogen Activator antibodyAnti-T-Pa antibodyAnti-T-Plasminogen Activator antibodyAnti-Tpa antibodyAnti-Alteplase antibodyAnti-Reteplase Cleaved Into-Tissue-Type Plasminogen Activator Chain A-Tissue-Type Plasminogen Activator Chain B antibodyAnti-PLAT antibody |
Protein name |
Tissue-Type Plasminogen ActivatorT-PaT-Plasminogen ActivatorTpaAlteplaseReteplase Cleaved Into-Tissue-Type Plasminogen Activator Chain A-Tissue-Type Plasminogen Activator Chain B |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.