Anti-HLA-DQB2 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P05538

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.

HLA-DQB2

Rabbit polyclonal against HLA-DQB2

Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
Golgi Apparatus
Trans-Golgi Network Membrane
Endosome Membrane
Lysosome Membrane
The Mhc Class Ii Complex Transits Through A Number Of Intracellular Compartments In The Endocytic Pathway Until It Reaches The Cell Membrane For Antigen Presentation

WB 1:500-1:2000

Hla Class Ii Histocompatibility Antigen-Dq Beta 2 Chain
Hla Class Ii Histocompatibility Antigen-Dx Beta Chain
Mhc Class Ii Antigen Dqb2

DQB2_HUMAN