Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human |
Isotype |
IgG |
Applications |
WB, FC, IHC |
Amount |
100ul |
Host |
Rabbit |
Item no. |
STJ116440-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P08684 |
Storage |
Store at 4° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide of human CYP3A4 |
Short Description |
Rabbit polyclonal against CYP3A4 |
Tissue specificity |
Expressed in prostate and liver. According to some authors, it is not expressed in brain. According to others, weak levels of expression are measured in some brain locations. Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). |
Cellular localization |
Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
Molecular weight |
Calculated: 57kDa. Observed: 57kDa |
Dilution range |
WB 1:500-1:1000 IHC 1:50-1:100 FC 1:20-1:50 |
Alternative names |
Anti-Cytochrome P450 3a4 antibodyAnti-1-4-Cineole 2-Exo-Monooxygenase antibodyAnti-1-8-Cineole 2-Exo-Monooxygenase antibodyAnti-Albendazole Monooxygenase antibodyAnti-Sulfoxide-Forming antibodyAnti-Albendazole Sulfoxidase antibodyAnti-Cypiiia3 antibodyAnti-Cypiiia4 antibodyAnti-Cholesterol 25-Hydroxylase antibodyAnti-Cytochrome P450 3a3 antibodyAnti-Cytochrome P450 Hlp antibodyAnti-Cytochrome P450 Nf-25 antibodyAnti-Cytochrome P450-Pcn1 antibodyAnti-Nifedipine Oxidase antibodyAnti-Quinine 3-Monooxygenase antibodyAnti-CYP3A4 CYP3A3 antibody |
Protein name |
Cytochrome P450 3a41-4-Cineole 2-Exo-Monooxygenase1-8-Cineole 2-Exo-MonooxygenaseAlbendazole MonooxygenaseSulfoxide-FormingAlbendazole SulfoxidaseCypiiia3Cypiiia4Cholesterol 25-HydroxylaseCytochrome P450 3a3Cytochrome P450 HlpCytochrome P450 Nf-25Cytochrome P450-Pcn1Nifedipine OxidaseQuinine 3-Monooxygenase |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.