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Acetohexamide

Acetohexamide

Item no.	TMO-T0816-100mg
Manufacturer	TargetMol
CASRN	968-81-0
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Aldawsari H, et al. Int J Pharm. 2013 Sep 10;453(2):315-21.
Smiles	CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Acetohexamid,Dymelor,Gamadiabet
Shipping Condition	Cool pack
Available
Manufacturer - Targets	NADPH\|\|\|Potassium Channel
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	324.4
Description	Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.
Pathways	Membrane transporter/Ion channel\|\|\|Metabolism
Bioactivity	Acetohexamide is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2; stimulate the pancreas to secrete insulin.
Receptor	NADPH; Potassium Channel

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