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Doxorubicin hydrochloride

Doxorubicin hydrochloride

Item no.	TMO-T1020-25mg
Manufacturer	TargetMol
CASRN	25316-40-9
Amount	25 mg
Quantity options	1000 mg 100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 g 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Sun W, et al. Y Res, 2009, 69(10), 4294-4300.
Smiles	Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	NSC 123127,Hydroxydaunorubicin hydrochloride,Adriamycin HCl,DOX hydrochloride
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Autophagy\|\|\|HIV Protease\|\|\|Mitophagy\|\|\|AMPK\|\|\|ADC Cytotoxin\|\|\|HBV\|\|\|Apoptosis\|\|\|Topoisomerase\|\|\|Antibacterial\|\|\|Antibiotic
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	579.99
Description	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
Pathways	DNA Damage/DNA Repair\|\|\|Antibody-drug Conjugate/ADC Related\|\|\|Apoptosis\|\|\|Chromatin/Epigenetic\|\|\|Proteases/Proteasome\|\|\|Microbiology/Virology\|\|\|PI3K/Akt/mTOR signaling\|\|\|Autophagy
Bioactivity	Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
Receptor	Topo II

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