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2-Methoxyestradiol

2-Methoxyestradiol

Item no.	TMO-T2220-100mg
Manufacturer	TargetMol
CASRN	362-07-2
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Breast Cancer
Type	Molecules
Specific against	other
Purity	0,98
Smiles	[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H]
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	NSC-659853,2-MeOE2,2-ME2
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Endogenous Metabolite\|\|\|Apoptosis\|\|\|Microtubule Associated\|\|\|Reactive Oxygen Species\|\|\|Autophagy\|\|\|HIF
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	302.41
Description	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
Pathways	NF-κB\|\|\|Apoptosis\|\|\|Cytoskeletal Signaling\|\|\|Chromatin/Epigenetic\|\|\|Immunology/Inflammation\|\|\|Autophagy\|\|\|Angiogenesis\|\|\|Metabolism

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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