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2-Methoxyestradiol

2-Methoxyestradiol

Item no.	TMO-T2220-1ml
Manufacturer	TargetMol
CASRN	362-07-2
Amount	1 mL
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	NSC-659853,2-MeOE2,2-ME2
Similar products	362-07-2
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Endogenous Metabolite\|\|\|Apoptosis\|\|\|Microtubule Associated\|\|\|Reactive Oxygen Species\|\|\|Autophagy\|\|\|HIF
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	302.41
Description	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
Pathways	NF-κB\|\|\|Apoptosis\|\|\|Cytoskeletal Signaling\|\|\|Chromatin/Epigenetic\|\|\|Immunology/Inflammation\|\|\|Autophagy\|\|\|Angiogenesis\|\|\|Metabolism

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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