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RGB-286638 free base

RGB-286638 free base

Item no.	TMO-T2378-1ml
Manufacturer	TargetMol
CASRN	784210-88-4
Amount	1 mL
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C29H35N7O4
Smiles	COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	CDK,JAK,MEK,JAK,JAK,JAK,GSK-3,GSK-3
Similar products	784210-88-4
Shipping Condition	Cool pack
Available
Manufacturer - Targets	MEK\|\|\|GSK-3\|\|\|JAK\|\|\|CDK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	545.63
Description	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
Pathways	Cell Cycle/Checkpoint\|\|\|Stem Cells\|\|\|JAK/STAT signaling\|\|\|Chromatin/Epigenetic\|\|\|PI3K/Akt/mTOR signaling\|\|\|Angiogenesis\|\|\|Tyrosine Kinase/Adaptors\|\|\|MAPK
Bioactivity	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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