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Cediranib

Cediranib

Item no.	TMO-T2500-2mg
Manufacturer	TargetMol
CASRN	288383-20-0
Amount	2 mg
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,99
Citations	1. Wedge SR, et al. Y Res. 2005 May 15; 65(10):4389-400.
Smiles	O(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=CN1)C=4C(F)=C5C(=CC4)NC(C)=C5
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	AZD2171, NSC-732208
Shipping condition	Cool pack
Available
Manufacturer - Targets	FLT\|\|\|PDGFR\|\|\|VEGFR\|\|\|c-Kit\|\|\|Autophagy
	KIT
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	450, 51
Target names or alias	AZD2171 , NSC-732208
Description	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit, selective more for VEGFR than PDGFR-α (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.
Pathways	Angiogenesis\|\|\|Autophagy\|\|\|Tyrosine Kinase/Adaptors

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