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LY2811376

LY2811376

Item no.	TMO-T2639-1ml
Manufacturer	TargetMol
CASRN	1194044-20-6
Amount	1 mL
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Beta-Secretase,Beta Amyloid,BACE
Similar products	1194044-20-6
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Beta Amyloid\|\|\|BACE\|\|\|Beta-Secretase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	320.36
Description	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
Pathways	Neuroscience

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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