« Back
Home /
Merestinib

Merestinib

Item no.	TMO-T3455-2mg
Manufacturer	TargetMol
CASRN	1206799-15-6
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,95
Citations	1.Yan SB, Peek VL, Ajamie R, et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. Invest New Drugs. 2012 Dec 29. [Epub ahead of print]
Smiles	O(C1=C(C=C2C(=C1)C=NN2C)C=3C=NNC3)C4=C(F)C=C(NC(=O)C=5C(=O)N(C(C)=CC5)C6=CC=C(F)C=C6)C=C4
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	LY2801653
Shipping Condition	Cool pack
Available
Manufacturer - Targets	c-Met/HGFR\|\|\|FLT\|\|\|ROS Kinase\|\|\|Discoidin Domain Receptor (DDR)\|\|\|ROS
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	552.53
Description	Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.
Pathways	Immunology/Inflammation\|\|\|Angiogenesis\|\|\|Tyrosine Kinase/Adaptors

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T3455-2mg-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 2 mg

available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question