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Linsitinib

Linsitinib

Item no.	TMO-T6017-100mg
Manufacturer	TargetMol
CASRN	867160-71-2
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Neural Signaling Reagents & Chemicals Molecules By Organ Heart & Blood Cancer
Type	Molecules
Specific against	other
Citations	1. Mulvihill MJ, et al. Future Med Chem, 2009, 1(6), 1153-1171.
Smiles	NC=1C=2N(C(=NC2C3=CC4=C(C=C3)C=CC(=N4)C5=CC=CC=C5)[C@H]6C[C@@](C)(O)C6)C=CN1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	OSI-906
Shipping Condition	Cool pack
Available
Manufacturer - Targets	IGF-1R
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	421.49
Description	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.
Pathways	Tyrosine Kinase/Adaptors

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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