BMS-1

Item no.	TMO-T3655-100mg
Manufacturer	TargetMol
CASRN	1675201-83-8
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Melanoma Sarcoma Myelofibrosis Mesothelioma Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Chupak Louis S,et al. From PCT Int. Appl. (2015), WO 2015034820 A1 20150312.
Smiles	COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CN1CCCC[C@H]1C(O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|PD-1/PD-L1
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	475.58
Description	BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
Pathways	Apoptosis\|\|\|Cell Cycle/Checkpoint\|\|\|Immunology/Inflammation

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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