TMP195

Item no.	TMO-T3983-10mM
Manufacturer	TargetMol
CASRN	1314891-22-9
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Neuroscience Neural Epigenetics Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Lobera M., et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.
Smiles	CC(C)(CNC(=O)c1cccc(c1)-c1noc(n1)C(F)(F)F)c1coc(n1)-c1ccccc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	TFMO 2,TMP 195
Shipping Condition	Cool pack
Available
Manufacturer - Targets	HDAC
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	456.42
Description	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.
Pathways	DNA Damage/DNA Repair\|\|\|Chromatin/Epigenetic
Bioactivity	Selective and cell-active class IIa histone deacetylase (HDAC) inhibitor, with IC50 values of 111, 106, 46, 9 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively; >100 fold more selective vs other HDACs (IC50: >10 uM).The trifluoromethyloxadiazole (TFMO) moiety in TMP 195 as a new metal binding group circumvents the selectivity and pharmacologic liabilities of hydroxamates groups used in other metalloenzyme inhibitors. TMP 195 has a restraint impact on gene expression, and lacks overt cytotoxicity.
Receptor	HDAC4; HDAC5; HDAC7; HDAC9

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mL x 10 mM (in DMSO)

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