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Sulfatinib

Sulfatinib

Item no.	TMO-T4075-10mM
Manufacturer	TargetMol
CASRN	1308672-74-3
Amount	1 mL x 10 mM (in DMSO)
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
Citations	1. PCT Int. Appl. (2011), WO 2011060746 A1 20110526.
Smiles	CN(C)CCNS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4[nH]c(C)cc4c3)n2)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	KDR-IN-1
Shipping Condition	Cool pack
Available
Manufacturer - Targets	VEGFR\|\|\|FGFR\|\|\|Potassium Channel
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	480.58
Description	Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24 nM.
Pathways	Membrane transporter/Ion channel\|\|\|Angiogenesis\|\|\|Tyrosine Kinase/Adaptors
Bioactivity	Sulfatinib may be a potent drug for cancer. It inhibits KDR and FGFR1 enzymatic activity, with IC50 values of 0.021 and 0.053 uM, respectively. Also, it is a hERG inhibitor with IC50 of 6.8 uM in CHO cell.
Receptor	FGFR1; hERG; KDR

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Amount: 1 mL x 10 mM (in DMSO)

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