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Buclizine dihydrochloride

Buclizine dihydrochloride

Item no.	TMO-T6426-100mg
Manufacturer	TargetMol
CASRN	129-74-8
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 1 g 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Mostafa GA, et al. Profiles Drug Subst Excip Relat Methodol, 2011, 36:1-33.
Smiles	CC(C)(C)c1ccc(cc1)CN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)Cl.Cl.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Longifene,Buclina,Buclizine HCl,UCB-4445
Shipping Condition	Cool pack
Available
Manufacturer - Targets	5-HT Receptor\|\|\|Histamine Receptor\|\|\|AChR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	505.95
Description	Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine dihydrochloride exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.
Pathways	GPCR/G Protein\|\|\|Neuroscience\|\|\|Immunology/Inflammation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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