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Buclizine dihydrochloride

Buclizine dihydrochloride

Item no.	TMO-T6426-1mL
Manufacturer	TargetMol
CASRN	129-74-8
Amount	1 mL
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 1 g 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CC(C)(C)c1ccc(cc1)CN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)Cl.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Longifene,Buclina,Buclizine HCl,UCB-4445
Similar products	129-74-8
Shipping Condition	Cool pack
Available
Manufacturer - Targets	5-HT Receptor\|\|\|Histamine Receptor\|\|\|AChR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	505.95
Description	Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine dihydrochloride exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.
Pathways	GPCR/G Protein\|\|\|Neuroscience\|\|\|Immunology/Inflammation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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