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Recombinant CTLA-4 Extracellular Domain ＆ Fc fragment (human IgG1 isotype) Protein

Recombinant CTLA-4 Extracellular Domain ＆ Fc fragment (human IgG1 isotype) Protein

Item no.	YR0046-5mg
Manufacturer	Abclonal
Amount	5 mg
Quantity options	1 mg 20 mg 5 mg
Category	ELISA Immunostaining Functional Assays Neutralization
Applications	ELISA, FA, NT
Specific against	other
Isotype	IgG1
Purity	>95% Determined by SDS-PAGE
NCBI	CTLA-4
Alias	ALPS5,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,IDDM12
Available
Manufacturer - Applications	ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways
Manufacturer - Category	Biosimilar
Manufacturer - Conjugate / Tag	<5% Determined by SECP
Storage Conditions	2 - 8°C for up to 4 weeks and -80°C for long term storage (Avoid repeated freezing and thawing)
Background	Belatacept (trade name Nulojix, Bristol-Myers-Squibb), a fusion protein of a Fc fragment (human IgG1 isotype) and the extracellular domain of CTLA-4, can be used to extend graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors. Belatacept differs from abatacept (trade name Orencia) by only 2 amino acids.The CTLA-4 protein is important for T-cell costimulation and selectively blocks the process of T-cell activation.
Manufacturer - Cross Reactivity	<1EU/mg (<0.001EU/μg)Determined by LAL gel clotting assay
Recommended Dilution	In Vivo Grade Recombinant Human IgG1 Fc Protein
Route	1×PBS pH 7.0
Manufacturer - Research Area	Cancer immunology
Gene Symbol	CTLA-4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 12/4/2025

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