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Recombinant Human Activator of 90KDA heat shock protein ATPase homolog 1(AHSA1)

Recombinant Human Activator of 90KDA heat shock protein ATPase homolog 1(AHSA1)

Hersteller	Cusabio
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Menge	200ug
Host	E.coli
ArtNr	CSB-RP054544h-200
eClass 6.1	34160400
eClass 9.0	42020190
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Research Topic	Neuroscience
Uniprot ID	O95433
Gene Names	AHSA1
Organism	Homo sapiens (Human)
AA Sequence	MAKWGEGDPRWIVEERADATNVNNWHWTERDASNW STDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASI NNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEI PNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEG VKLLREAMGIYISTLKTEFTQGMILPTMNGESVDP VGQPALKTEERKAKPAPSKTQARPVGVKIPTCKIT LKETFLTSPEELYRVFTTQELVQAFTHAPATLEAD RGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWP EGHFATITLTFIDKNGETELCMEGRGIPAPEEERT RQGWQRYYFEGIKQTFGYGARLF
Expression Region	1-338aa
Sequence Info	Full Length
Source	E.coli
Tag Info	N-terminal GST-tagged
MW	65.3 kDa
Alternative Name(s)	p38
Relevance	Cochaperone that stimulates HSP90 ATPase activity . May affect a step in the endoplasmic reticulum to Golgi trafficking.
Reference	Isolation of a novel gene underexpressed in Down syndrome.Michaud J., Chrast R., Rossier C., Papassavas M.P., Antonarakis S.E., Scott H.S.Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins
Subcellular Location	Cytoplasm, cytosol, Endoplasmic reticulum
Protein Families	AHA1 family
Tissue Specificity	Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

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