|
Hersteller |
GenScript |
|
Kategorie |
|
|
Typ |
Proteins |
|
Specific against |
Human |
|
Menge |
5.0ug |
|
ArtNr |
Z02984-5 |
|
eClass 6.1 |
34160400 |
|
eClass 9.0 |
42020190 |
|
Lieferbar |
 |
| Product Line |
Cytokines, Chemokines & Growth Factors |
| Description |
Fibroblast Growth Factor-4 (FGF-4), also known as K-FGF is a heparin-binding growth factor of the FGF family.It was identified by its oncogenic transforming activity. FGF-4 and FGF-3 are located closely on chromosome 11. FGF-4 and its receptors (FGF R1c, 2c, 3c and 4) play an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. FGF-4 is required for normal limb and cardiac valve development during embryogenesis. Recombinant, human Fibroblast Growth Factor-4 (rhFGF-4), produced in, E. coli, is a single non-glycosylated polypeptide chain containing 177 amino acids. A fully biologically active molecule obtained by proprietary chromatographic techniques at GenScript, rhFGF-4 has a molecular mass of 19.4kDa as analyzed by reducing SDS-PAGE. |
| M.W. |
19.4kDa, observed by reducing SDS-PAGE. |
| Purity |
> 95% by SDS-PAGE and HPLC analyses. |
| Endotoxin Level |
<0.2 EU/ug, determined by LAL method. |
| Specific Activity |
ED50 2.0x 106 units/mg. |
| Storage |
Lyophilized recombinant, human Fibroblast Growth Factor-4 (rhFGF-4), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhFGF-4 should be stable up to 2 weeks at 4C or up to 3 months at -20C. |
| Formulation |
Lyophilized after extensive dialysis against 50mM HEPES, 750mM NaCl, pH7.5. |
| Reconstitution |
Reconstituted in ddH2O at 100 ug/ml. |
| Sequence |
Ala31-Leu206 (accession number:P08620), expressed with an N-terminal Met. |
| Note |
For research use only |
