CCL2

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human
Applications	WB, FC, IF, IHC
Protein Family	Lymphocyte Signaling
Amount	100ug
Host	Rabbit
Item no.	A0313
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	11kDa
Immunogen	A synthetic peptide of human CCL2
Gene ID	6347
Swiss Prot	P13500
Synonyms	MCP-1; MCAF; HC11; SCYA2; MCP1; CCL2
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, monocyte chemotactic activating factor (MCAF) or glioma-derived chemotactic factor-2 (GDCF-2), is the product of the human JE gene and a member of the family of C-C (or ?) chemokines (1-4). The predicted molecular weight of MCP-1 protein is 11-13 kDa, but it may migrate at 20-30 kDa due to glycosylation. MCP-1 is secreted by a variety of cell types in response to pro-inflammatory stimuli and was originally described for its chemotactic activity on monocytes. This activity has led to studies demonstrating its role in diseases characterized by monocyte infiltrates such as psoriasis (5), rheumatoid arthritis (6) and atherosclerosis (7). MCP-1 may also contribute to tumor progression and angiogenesis (8). Signaling by MCP-1 is mediated by the G-protein coupled receptor CCR2 (9).
Recommended Dilutions	WB 1:200-1:500 IHC 1:50-1:100 IF 1:20-1:50 FC 1:20-1:50
illustration	Western blot analysis of HeLa cell lysate using CCL2 antibody.

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