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IRE1alpha

IRE1alpha

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human
Applications	WB
Protein Family	Protein Folding/Stability
Amount	100ug
Host	Rabbit
Item no.	A0615
eClass 6.1	32160702
eClass 9.0	32160702
Available
Calculated MW	109kDa
Immunogen	A synthetic peptide of human ERN1
Synonyms	IRE1, Endoplasmicreticulum-to-nucleussignaling1, Inositol-requiring protein1, Ire1-alpha, Serine/threonine-protein kinase, Endoribonuclease
Purity	Affinity purification
Storage Buffer	Store at 4C or -20C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Illustration	Western blot analysis of extracts of ZR-75-1 cell line, using ERN1 antibody.
Gene Symbol	ERN1
GeneID (Human)	2081
GeneID	2081
Protein MW	977
SWISS	O75460
Route	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.