4E-BP1

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human
Applications	WB, FC, IHC
Protein Family	Translational Control
Amount	100ug
Host	Rabbit
Item no.	A0787
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	13kDa
Immunogen	Recombinant protein of human EIF4EBP1
Gene ID	1978
Swiss Prot	Q13541
Synonyms	BP-1; 4EBP1; 4E-BP1; PHAS-I;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Recommended Dilutions	WB 1:500-1:1000 IHC 1:50-1:100 FC 1:20-1:50
illustration	Western blot analysis of extracts of T47D celllines, using EIF4EBP1antibody.

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