GCK

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human, Mouse
Applications	WB, IF, IHC
Protein Family	MAPK Signaling
Amount	100ug
Host	Rabbit
Item no.	A0430
eClass 6.1	32160702
eClass 9.0	32160702
Available
Calculated MW	52kDa
Immunogen	A synthetic peptide of human GCK
Synonyms	GCK, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2
Purity	Affinity purification
Storage Buffer	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Germinal center kinase (GCK) is the founding member of the GCK family, a group of serine/threonine kinases homologous to the yeast Ste20 kinase. GCK is activated by TNF and associated with TRAF2 (TNF receptor-associated factor 2) and MEKK1, thereby activating the SAPK/JNK pathway (1, 2). GCK does not significantly phosphorylate MEKK1, instead it enhances MEKK1 oligomerization and autophosphorylation (3). GCK binds and activates MLK3, indicating that GCK may have other effectors (3).
Illustration	Western blot analysis of extracts of HepG2 celland livercell line, using GCK antibody.
Gene Symbol	GCK
GeneID (Human)	2645
GeneID	2645
Protein MW	465
SWISS	P35557
Route	Synthetic Peptide

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