BCL6

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human, Mouse
Applications	WB, FC, IHC
Protein Family	Lymphocyte Signaling
Amount	100ug
Host	Rabbit
Item no.	A0477
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	79kDa
Immunogen	A synthetic peptide of human BCL6
Gene ID	604
Swiss Prot	P41182
Synonyms	BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Recommended Dilutions	WB 1:500-1:1000 IHC 1:50-1:100 FC 1:20-1:50
illustration	Western blot analysis of extracts of mouse cerebellum celllines, using BCL6antibody.

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