Pan Cadherin Rabbit mAb

Monoclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

A synthetic peptide corresponding to a sequence within amino acids 806-906 of human Cadherin-2 (CDH2) (P19022).

140kDa

Apoptosis, Calcium Signaling, Cancer, CDs, Cell Adhesion, Cell Adhesion_Cadherins, Cell Adhesion_Tight Junctions, Cell Biology & Developmental Biology, Cell Cycle, Cell Cycle_Centrosome, Cytoskeleton, ErbB-HER Signaling Pathway, Immunology & Inflammation, Invasion and Metastasis, Neuroscience, Signal Transduction, Wnt/β-Catenin Signaling Pathway.

999/1000/1001/1002

CDH1/CDH2/CDH3/CDH4