PKCbeta1 polyclonal antibody

P05771(Human) P68404(Mouse) P68403(Rat)

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes, including conventional (c) PKC isoforms (alpha, betaI, betaII and gamma) and novel (n) PKC isoformsandny. Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC delta and epsilon are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.

ProA affinity purified

PKCbeta1 polyclonal antibody detects endogenous levels of PKCbeta1 protein.

For research use only, not for use in diagnostic procedure.