GRM6 Antibody

O15303

ELISA, WB, IHC, WB:1:500-1:3000, IHC:1:50-1:100

WB:1:500-1:3000

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity. Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.

Inga Everts, J. Neurosci., Feb 1999, 19: 916.
Gregory D. Salinas, J. Biol. Chem., Dec 2006, 281: 40164 - 40173.
Sheng Yan, J. Neurosci., Jan 2004, 24: 679.
Xiao-Mei Liu, J. Biol. Chem., Jun 2006, 281: 17432 - 17445.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Neuroscience